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Here we discuss recent insights into the regulation of this pathway in cancer immunosurveillance, and the downstream signaling cascades that coordinate immune cell recruitment to the tumor microenvironment to destroy transformed cells through cellular senescence or cell death programs.
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This is achieved through the cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon (IFN) genes (STING) pathway. However, recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. The host innate immunity offers the first line of defense against infection. 1 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeĢ National University Health System (NUHS), Singaporeģ Wong Hock Boon Society, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeĤ Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singaporeĥ NUS Graduate School of Integrative Sciences & Engineering (NGS), National University of Singapore, SingaporeĬorrespondence to: Brandon Yi Da Sin cyclic GMP-AMP synthase stimulator of interferon cGAS STING interferon